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Amphetamines are acknowledged to be metabolized, to some degree, by cytochrome P450 2D6 (CYP2D6) and Exhibit minor inhibition of CYP2D6 metabolism; likely for a pharmacokinetic interaction exists with coadministration of CYP2D6 inhibitors which may enhance threat with increased publicity to amphetamines; in these cases, look at option non-serotoner